项目: 1. 国家自然科学基金项目：具有聚集诱导发光特性的近红外荧光聚合物的合成及其肿瘤荧光成像性能的研究，(No. 21504064，2016/01-2018/12)，20万，负责人。 2. 天津市面上科学基金：逐级智能响应型光动力治疗与化疗协同纳米前药的研制，(No. 19JCYBJC18000，2019/04-2022/03)，10万，负责人。 3. 天津市青年科学基金：肿瘤微酸环境响应型高亮度近红外荧光聚合物的制备，(No. 16JCQNJC02800，2016/04-2019/03)，6万，负责人。 4. 天津市教委科研基金：近红外聚集诱导发光聚合物的合成及其生物成像研究，(No. 20140501，2014/09-2016/09)，4万，负责人。 5. 天津市“131”创新型人才培养工程，第三层次，(2013/10-2015/9)，3万，负责人。 论文: 1. X. Wang, L. Liu, L. Wang, L. Guo, Y. Li, B. Bai, F. Fu, H. Lu* and X. Zhao*. Optimizing comprehensive performance of aggregation-induced emission nanoparticles through molecular packing modulation for multimodal image-guided synergistic phototherapy. Adv. Healthcare Mater. 2021, 10, 2100360. 2. L. Liu, X. Wang, L. Wang, L. Guo, Y. Li, B. Bai, F. Fu, H. Lu* and X. Zhao*. One-for-all phototheranostic agent based on aggregation-induced emission characteristics for multimodal imaging-guided synergistic photodynamic/photothermal cancer therapy. ACS Appl. Mater. Interfaces, 2021, 13, 19668-19678. 3. Y. Li, X. Wang, L. Zhang, L. Liu, Q. Wang, H. Lu* and X. Zhao*. Remarkable solid-state fluorescence change from the visible to the near-infrared region based on the protonation/deprotonation of an AIEgen. Mater. Chem. Front., 2020, 4, 3378-3383. 4. Y. Zhang, X. Zhao, Y. Li, X. Wang, Q. Wang, H. Lu* and L. Zhu*. A fluorescent photosensitizer with far-red/near-infrared aggregation-induced emission for imaging and photodynamic killing of bacteria. Dyes Pigments, 2019, 165, 53-57. 5. J. Zou, H. Lu*, X. Zhao, W. Li, Y. Guan, Y. Zheng, L. Zhang and H. Gao*. A multi-functional fluorescent probe with aggregation-induced emission characteristics: mitochondrial imaging, photodynamic therapy and visualizing therapeutic process in zebrafish model. Dyes Pigments, 2018, 151, 45-53. 6. Y. Zheng, H. Lu*, Z. Jiang, Y. Guan, J. Zou, X. Wang, R. Cheng and H. Gao*. Low-power white light triggered AIE polymer nanoparticles with high ROS quantum yield for mitochondria-targeted and image-guided photodynamic therapy. J. Mater. Chem. B, 2017, 5, 6277-6281. 7. Y. Guan, H. Lu*, W. Li, Y. Zheng, Z. Jiang, J. Zou and H. Gao*. Near-infrared triggered upconversion polymeric nanoparticles based on aggregation-induced emission and mitochondria targeting for photodynamic cancer therapy. ACS Appl. Mater. Interfaces, 2017, 9, 26731-26739. 8. H. Lu*, Y. Zheng, X. Zhao, L. Wang, S. Ma, X. Han, B. Xu, W. Tian and H. Gao*. Highly efficient far red/near-infrared solid fluorophores: aggregation-induced emission, intramolecular charge transfer, twisted molecular conformation, and bioimaging applications. Angew. Chem. Int. Ed., 2016, 55, 155-159. ESI高被引论文, 它引260余次. 专利： 1. 一种高聚集态荧光发射的荧光标记分子及其制备方法，授权专利号：ZL201510246913.6。 2. 一种近红外激光驱动的线粒体靶向荧光聚合物及其制备方法及应用，授权专利号：ZL201710306591.9。 3. 一种低功率白光驱动的线粒体靶向荧光探针光敏剂及其合成方法及应用，授权专利号：ZL201710927606.3。 4. 一种固态酸碱刺激响应的近红外荧光化合物的制备方法与应用，授权专利号：ZL201910861168.4。 获奖: 1、天津市自然科学二等奖（2019年度），超分子自组装在药物递送与生物成像中的应用基础研究，第三完成人。 |
