姓名

戴霞林

性别

女

出生年月

1993.11

学历学位

博士

职称

讲师

系别

制药工程系

导师类型

硕导

电话

022-60214719

Email

daixialin@email.tjut.edu.cn

办公/

科研室

19号楼202室

硕导所属学科

100701 药物化学

研究

方向

1. 药物晶型、共晶、盐型等固体形态研究

2. 离子液体药物研究

讲授

课程

本科生课程：药物分析学（双语），制药工程专业开放实验

主要科研项目及代表性成果(包括鉴定项目、论文、专著、获奖、专利等)：

项目:

1、国家自然科学基金青年科学基金项目：基于低共熔溶剂的药物共晶合成及其机制研究（22101204），2022.01-2024.12，30万，第一；

2、国家自然科学基金面上项目：抗肿瘤药-药纳米共晶的可控合成与增溶增效研究（22271220），2023.01-2026.12，54万，第三；

3、横向课题：甾体激素类药物共晶的固态分析研究，5万，第一。

论文:

1. Guan-Lan Huang¹, Ling Yang¹, Bo-Ying Ren, Xin-Yue Lv, Ling-Yi Song, Xia-Lin Dai*, Jia-Mei Chen*, Simultaneously Improving the Physicochemical and Pharmacokinetic Properties of Vemurafenib through Cocrystallization Strategy. J. Drug Deliv. Sci. Tec. 2022, 70, 103230.

2. Jun-Long Jia, Xia-Lin Dai,* Hao-Jie Che, Meng-Ting Li, Xiao-Mei Zhuang, Tong-Bu Lu and Jia-Mei Chen,* Cocrystals of Regorafenib with Dicarboxylic Acids: Synthesis, Characterization and Property Evaluation. CrystEngComm 2021, 23, 653−662.

3. Jie Wang, Xia-Lin Dai,* Tong-Bu Lu and Jia-Mei Chen,* Temozolomide−Hesperetin Drug−Drug Cocrystal with Optimized Performance in Stability, Dissolution, and Tabletability. Cryst. Growth Des. 2021, 21, 838−846.

4. Bo-Ying Ren, Xia-Lin Dai,* Jie Wang, Chao Wu, Tong-Bu Lu and Jia-Mei Chen*, Cocrystallization of Axitinib with Carboxylic Acids: Preparation, Crystal Structures and Dissolution Behavior. CrystEngComm 2021,23, 5504−5515.  

5. Xia-Lin Dai, Jia Yao, Jun-Hui Deng, Yong-Hui Mo, Tong-Bu Lu and Jia-Mei Chen,* Solubility and Permeability Improvement of Allopurinol by Cocrystallization. Cryst. Growth Des. 2020, 20, 5160−5168.

6. Xia-Lin Dai, Chao Wu, Jin-Hui Li, Lian-Chao Liu, Xin He, Tong-Bu Lu and Jia-Mei Chen,* Modulating the Solubility and Pharmacokinetic Property of 5-Fluorouracil via Cocrystals. CrystEngComm 2020, 22, 3670−3682.

7. Xia-Lin Dai, Alexander P. Voronin, Yong-Liang Huang, German L. Perlovich, Xing-Hua Zhao, Tong-Bu Lu and Jia-Mei Chen,* 5-Fluorouracil Cocrystals with Lipophilic Hydroxy-2-Naphthoic Acids: Crystal Structures, Theoretical Computations and Permeation Studies. Cryst. Growth Des. 2020, 20, 923−933.

8. Xia-Lin Dai, Alexander P. Voronin, Wei Gao, German L. Perlovich, Tong-Bu Lu and Jia-Mei Chen,* Intermolecular Interactions and Permeability of 5-Fluorouracil Cocrystals with a Series of Isomeric Hydroxybenzoic Acids: a Combined Theoretical and Experimental Study. CrystEngComm 2019, 21, 5095−5105.

9. Xia-Lin Dai, Jia-Mei Chen* and Tong-Bu Lu,* Pharmaceutical Cocrystallization: an Effective Approach to Modulate the Physicochemical Properties of Solid-State Drugs. CrystEngComm 2018, 20, 5292−5316.

10. Xia-Lin Dai, Song Li, Jia-Mei Chen* and Tong-Bu Lu, Improving the Membrane Permeability of 5‑Fluorouracil via Cocrystallization. Cryst. Growth Des. 2016, 16, 4430−4438.

专利：

1. 陈嘉媚，吕文婷，戴霞林，一种奥拉帕尼与马来酸的共晶及其制备方法，中国发明专利，申请日2020.7.22，授权公告日2021.12.3，专利号202010708667.2。

2. 陈嘉媚，贾军龙，戴霞林，授权公告日2021.12.3，一种瑞戈非尼与马来酸的共晶及其制备方法，中国发明专利，申请日2020.8.7，授权公告日2021.12.3，专利号202010787157.9。

3. 戴霞林，吕文婷，陈嘉媚，一种奥拉帕尼与丙二酸的共晶及其制备方法，专利号202010707895.8。

4. 戴霞林，贾军龙，李梦婷，陈嘉媚，一种瑞戈非尼与辛二酸的共晶及其制备方法，专利号202010702741.X。